NEW YORK (Reuters Health)
Adherence to a metformin-based preventive strategy in the Diabetes Prevention Program (DPP) was variable, depending on barriers and compliance strategies. However, participants who were adherent had a reduced risk of developing diabetes, according to findings published in the September issue of Diabetes Care.
The DPP investigated the value of intensive lifestyle intervention or metformin in delaying or preventing type 2 diabetes in high-risk individuals with impaired glucose tolerance.
Dr. Elizabeth A. Walker, of George Washington University, Rockville, Maryland, and colleagues examined medication adherence and health outcomes in the metformin and placebo arms of the DPP. They also assessed barriers to adherence and strategies for medication adherence.
A total of 2155 subjects who were randomly assigned to either the metformin or placebo treatment arms were included in the analysis. The overall adherence rates (the proportion of patients taking at least 80% of the prescribed dose) were 71% in the metformin group and 77% in the placebo group.
Among patients taking metformin, older age groups were more adherent than the youngest group (p = 0.01).
"Among both metformin and placebo arms, the most commonly reported barriers to taking DPP medication as prescribed were forgetting to take doses (22%), adverse effects (8%), and disruption of routines (8%)," Dr. Walker's team found. Overall, 15% of women and 10% of men reported adverse effects in the metformin group.
Participants who reported multiple strategies to take medications had increased odds of adherence (odds ratio 2.69, p < 0.0001).
Compared to patients who were adherent to placebo, those adherent to metformin had a 38.2% reduced risk of developing diabetes (p < 0.0003), the investigators report.
They conclude, "Our finding that the level of medication adherence predicted the primary outcome of diabetes lend support for future development and evaluation of brief, practical medication adherence interventions for primary care settings."
Powered by Qumana
1 comments:
The Alawite Regime in Syria is more commonly but wrongly known under the name of the Baath regime. This terminology is wrong since the idea of the Arab Baath died with its founder Michel Aflaq a long time ago. All what is left is a gang of criminals and sectarian haters.
Here are the six main points against this despicable regime.
This regime is guilty of high treason because:
1-it sold the Golan to Israel in exchange for Lebanon
2-it allied itself with the Persians in the Iran-Iraq war (1980-88) against the Arabs
3-it declared war on the Palestinian cause and on the Palestinian people, and it committed war crimes and massacres against them in Lebanon
4-it brutally occupied Lebanon for 30 years and committed mass murder and massacres against the Lebanese population
5-it left Syria in a state of under-development and mass poverty
6-and above all, it ruled the Syrian people with the armored fist for more than 35 years by filling the concentration camps of Tadmour and Mazzeh. All while committing acts of mass murder, annihilation (Hama 1982), atrocity, rape, torture, and mass deportation against anyone who dared to speak up against their absolute rule.
Post a Comment